Contraindicated. amobarbital and doxepin both increase sedation. Modify Therapy/Monitor Closely. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases effects of doxepin by unknown mechanism. Use Caution/Monitor. Use Caution/Monitor.Minor (1)doxepin increases levels of atropine IV/IM by unknown mechanism. Concomitant use could result in life-threatening serotonin syndrome. metaxalone and doxepin both increase sedation. trihexyphenidyl and doxepin both decrease cholinergic effects/transmission. Effect of interaction is not clear, use caution. Monitor Closely (1)clonazepam and doxepin both increase sedation. Avoid or Use Alternate Drug. 2021 Dec;238(12):3357-3373. doi: 10.1007/s00213-021-05950-4. Avoid or Use Alternate Drug. This site complies with the HONcode standard for trustworthy health information: verify here. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug.doxepin, epinephrine. Either increases effects of the other by pharmacodynamic synergism. https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics. Monitor Closely (1)doxepin and dasatinib both increase QTc interval. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Other (see comment). Effect of interaction is not clear, use caution. carbachol increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. doxepin and aripiprazole both increase QTc interval. Antidepressants: Which cause the fewest sexual side effects? Monitor Closely (1)chloral hydrate and doxepin both increase sedation. Use Caution/Monitor. https://www.fda.gov/consumers/consumer-updates/depression-fda-approved-medications-may-help. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and chloroquine both increase QTc interval. benzhydrocodone/acetaminophen, doxepin. doxepin increases and ephedrine decreases sedation. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. Either increases toxicity of the other by pharmacodynamic synergism. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. doxepin and disopyramide both increase QTc interval. selegiline transdermal and doxepin both increase serotonin levels. loxapine and doxepin both increase sedation. Monitor Closely (1)doxepin and mifepristone both increase QTc interval. This site needs JavaScript to work properly. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely.doxepin and lithium both increase QTc interval. Modify Therapy/Monitor Closely. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. Avoid or Use Alternate Drug. Monitor Closely (3)doxepin and iloperidone both increase QTc interval. Monitor Closely (2)desflurane and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dopexamine. Either increases effects of the other by sedation. Accessed Sept. 12, 2019. Use Caution/Monitor. Avoid or Use Alternate Drug.desipramine and doxepin both increase serotonin levels. Minor/Significance Unknown. Either increases effects of the other by serotonin levels. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. The National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. Monitor Closely (2)cobicistat will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. Avoid or Use Alternate Drug. Publication types Clinical Trial Comparative Study Controlled Clinical Trial Wellbutrin XL Interactions. Minor/Significance Unknown. Avoid or Use Alternate Drug. Monitor Closely (1)opium tincture and doxepin both increase sedation. Avoid or Use Alternate Drug. esketamine intranasal, doxepin. Monitor Closely (1)doxepin and amisulpride both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)doxepin increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and buspirone both increase serotonin levels. Monitor Closely (2)doxepin and risperidone both increase QTc interval. HHS Vulnerability Disclosure, Help Minor/Significance Unknown. levothyroxine increases effects of doxepin by Other (see comment). Monitor Closely (1)lormetazepam and doxepin both increase sedation. Typically, it may take several weeks or longer before an antidepressant is fully effective and for initial side effects to ease up. Effect of interaction is not clear, use caution. Use Caution/Monitor. Monitor Closely (1)doxepin and topiramate both increase sedation. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. tucatinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clobazam will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin and ranolazine both increase QTc interval. Clipboard, Search History, and several other advanced features are temporarily unavailable. dextromoramide and doxepin both increase sedation. other information we have about you. Minor/Significance Unknown. This report displays the potential drug interactions for the following 2 drugs: Applies to: Wellbutrin (bupropion) and doxepin. doxepin and ribociclib both increase QTc interval. Mechanism: unspecified interaction mechanism. Effect of interaction is not clear, use caution. Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system. Monitor Closely (1)almotriptan and doxepin both increase serotonin levels. Monitor Closely (1)ritonavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Cyclic antidepressants block the reabsorption (reuptake) of the neurotransmitters serotonin (ser-o-TOE-nin) and norepinephrine (nor-ep-ih-NEF-rin), increasing the levels of these two neurotransmitters in the brain. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. the unsubscribe link in the e-mail. Use Caution/Monitor. Use Caution/Monitor. pentazocine and doxepin both increase sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Minor/Significance Unknown. Use Caution/Monitor. U.S. Food and Drug Administration. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. Effect of interaction is not clear, use caution. Minor/Significance Unknown. doxepin increases and phendimetrazine decreases sedation. Mechanism: unspecified interaction mechanism. doxepin and propafenone both increase QTc interval. Concurrent use or use within 14 days of selegiline treatment is contraindicated. morphine and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (2)doxepin, oliceridine. Serious - Use Alternative (2)doxepin and ozanimod both increase QTc interval. Other (see comment). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Use Caution/Monitor.Minor (1)diphenhydramine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Either increases levels of the other by pharmacodynamic synergism. doxepin increases and epinephrine decreases sedation. 1991 Aug;52(8):329-35. Either increases levels of the other by pharmacodynamic synergism. J Clin Psychiatry. Monitor Closely (1)doxepin and ergotamine both increase serotonin levels. Monitor Closely (1)benzhydrocodone/acetaminophen, doxepin. Avoid or Use Alternate Drug. Use Caution/Monitor. You may opt-out of email communications at any time by clicking on Monitor Closely (1)doxepin increases and methylenedioxymethamphetamine decreases sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Other (see comment). Mechanism: unspecified interaction mechanism. Oxidative metabolism of TCAs may be decreased by ethinyl estradiol. prescription products. Use Caution/Monitor. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Use Caution/Monitor. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: problems urinating (urinary retention), personal or family history of glaucoma (angle-closure type).This drug may make you drowsy. doxepin and erythromycin stearate both increase QTc interval. Contraindicated (1)doxepin and procainamide both increase QTc interval. Avoid or Use Alternate Drug.doxepin and lumefantrine both increase QTc interval. Contraindicated. Use Caution/Monitor. Contraindicated. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, methylenedioxymethamphetamine. doxepin will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. Usually avoid combinations; use it only under special circumstances. Theoretical interaction. Use Caution/Monitor.Minor (2)doxepin, prochlorperazine. Mechanism: unspecified interaction mechanism. Contraindicated. commonly, these are "non-preferred" brand drugs. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in dextroamphetamine levels in brain; May be potentiate cardiovascular effects. Coadministration may increase risk of serotonin syndrome. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Modify Therapy/Monitor Closely.Minor (1)sulfamethoxazole decreases levels of doxepin by unspecified interaction mechanism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Use Caution/Monitor. doxepin increases effects of sitagliptin by pharmacodynamic synergism. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. To help you remember, take it at the same time each day.Tell your doctor if your condition lasts or gets worse after 7-10 days. Is Peanut Oil a Seed Oil? Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. For very mild anxiety, dosage as low as 25 to 50 mg per day may be used . bupropion will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. If we combine this information with your protected In some cases, where available, results of special blood tests may offer clues about how your body may respond to a specific antidepressant. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor.Minor (1)sevoflurane, doxepin. Signs and symptoms of serotonin syndrome include anxiety, agitation, high fever, sweating, confusion, tremors, restlessness, lack of coordination, major changes in blood pressure and a rapid heart rate. Contraindicated. Effect of interaction is not clear, use caution. Other (see comment). Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (2)glycopyrrolate inhaled and doxepin both decrease cholinergic effects/transmission. doxepin, clobazam. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Effect of interaction is not clear, use caution. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.Minor (1)sertraline will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Avoid or Use Alternate Drug. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Minor/Significance Unknown. Contraindicated (1)isocarboxazid and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Effect of interaction is not clear, use caution. Taking trazodone (Desyrel) with doxepin can increase the risk of serotonin syndrome, a rare, potentially life-threatening condition that can increase blood pressure and heart rate. Other (see comment). Avoid or Use Alternate Drug. Minor/Significance Unknown. Minor (1)parecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. pimozide and doxepin both increase sedation. tapentadol and doxepin both increase sedation. Additive impairment of motor skills. Minor (1)conjugated estrogens, vaginal, doxepin. Either increases effects of the other by pharmacodynamic synergism. Consult your doctor before breast-feeding. Alzheimer's nose spray: New Alzheimer's treatment? Use Caution/Monitor. Monitor Closely (1)naratriptan and doxepin both increase serotonin levels. doxepin, phentermine. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Estrogens may inhibit hepatic metabolism of tricyclic antidepressants. Monitor Closely (2)doxepin and salmeterol both increase QTc interval. Use lowest dose possible and monitor for respiratory depression and sedation. Use Caution/Monitor. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Monitor Closely (1)doxepin increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Genetics Home Reference. Severe Interactions These medications are not usually taken together. Use Caution/Monitor.doxepin and lofexidine both increase QTc interval. Additive CNS depression. What are opioids and why are they dangerous? Accessed Aug. 13, 2019. Other (see comment). Contraindicated. nalbuphine and doxepin both increase sedation. Use Caution/Monitor. Risk of arrhythmias or hypotension. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Use Caution/Monitor.Serious - Use Alternative (2)desipramine and doxepin both increase QTc interval. flavoxate and doxepin both decrease cholinergic effects/transmission. lefamulin will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)metaxalone and doxepin both increase sedation. doxepin, promazine. papaveretum and doxepin both increase sedation. Monitor Closely (1)doxepin and lsd both increase serotonin levels. How to tell if a loved one is abusing opioids. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. doxepin and risperidone both increase QTc interval. Other (see comment). Monitor Closely (1)doxepin and paroxetine both increase QTc interval. Modify Therapy/Monitor Closely. stiripentol, doxepin. Minor/Significance Unknown. Serious - Use Alternative (1)doxepin and ivosidenib both decrease QTc interval. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. If you or someone you know has suicidal thoughts when taking an antidepressant, immediately contact your doctor or get emergency help. Use Caution/Monitor. Like most antidepressants, cyclic antidepressants work by ultimately effecting changes in brain chemistry and communication in brain nerve cell circuitry known to regulate mood, to help relieve depression. Monitor Closely (1)onabotulinumtoxinA and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Accessed Aug. 19, 2019. Other (see comment). Avoid or Use Alternate Drug. Minor/Significance Unknown. Do not administer these drugs until at least 7 days after each iobenguane dose. thioridazine and doxepin both increase QTc interval. doxepin and asenapine both increase QTc interval. Use Caution/Monitor. Either increases effects of the other by Mechanism: pharmacodynamic synergism. May lower seizure threshold; keep bupropion dose as low as possible. Use Caution/Monitor. Monitor Closely (1)quazepam and doxepin both increase sedation. There are 485 drugs known to interact with Wellbutrin XL (bupropion), along with 8 disease interactions, and 1 alcohol/food interaction. Use Caution/Monitor. Use Caution/Monitor.belladonna and opium and doxepin both increase sedation. The https:// ensures that you are connecting to the Monitor Closely (1)ketamine and doxepin both increase sedation. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. There is a problem with Use Caution/Monitor. methscopolamine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin and lsd both increase serotonin levels. Tricyclic antidepressants such as imipramine, nortriptyline (Pamelor), amitriptyline, doxepin . phenelzine and doxepin both increase serotonin levels. Effect of interaction is not clear, use caution. Use Caution/Monitor. doxepin increases and norepinephrine decreases sedation. Risk of arrhythmias or hypotension. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. The effects may be increased because of slower removal of the medicine from the body. Minor/Significance Unknown. Other (see comment). Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug.Minor (2)doxepin, fluphenazine. Monitor Closely (1)doxepin increases and pirbuterol decreases sedation. Modify Therapy/Monitor Closely. Also, increased appetite and weight gain were consistent side effects of doxepin relative to bupropion. doxepin and protriptyline both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Taking doxepin with gabapentin (Neurontin) could therefore increase certain side effects of CNS depression, such as dizziness, confusion, and trouble concentrating. rivastigmine increases and doxepin decreases cholinergic effects/transmission. Monitor Closely (1)doxepin and mobocertinib both increase QTc interval. Monitor Closely (1)valerian and doxepin both increase sedation. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and droperidol both increase QTc interval. Monitor Closely (1)galantamine increases and doxepin decreases cholinergic effects/transmission. Either increases effects of the other by pharmacodynamic synergism. dicyclomine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and doxepin both increase QTc interval. doxepin and hydroxychloroquine sulfate both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)doxepin and triclabendazole both increase QTc interval. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)hydrocodone, doxepin. doxepin and lofexidine both increase sedation. Minor/Significance Unknown. Work with your doctor to gradually and safely decrease your dose. Properly discard this product when it is expired or no longer needed. Use Caution/Monitor.Serious - Use Alternative (1)granisetron, doxepin. Mayo Clinic does not endorse any of the third party products and services advertised. doxepin decreases effects of brimonidine by pharmacodynamic antagonism. tramadol and doxepin both increase sedation. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Minimally clinically significant. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Serious - Use Alternative (1)doxepin will decrease the level or effect of iobenguane I 131 by Other (see comment). Avoid or Use Alternate Drug. Minor/Significance Unknown. ECG monitoring is recommended.doxepin and citalopram both increase QTc interval. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor (1)doxepin increases effects of sitagliptin by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)efavirenz and doxepin both increase QTc interval. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Depression: FDA-approved medications may help. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and hydroxychloroquine sulfate both increase QTc interval. Concurrent use of toremifene with agents causing QT prolongation should be avoided. Modify Therapy/Monitor Closely. Both cannabis and . 8 In a strict sense, doxepin is not a tricyclic antidepressant . Consider dose reduction of sensitive CYP3A4 substrates. Other (see comment). dantrolene and doxepin both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin, buprenorphine subdermal implant. Information last revised January 2023. doxepin will decrease the level or effect of iobenguane I 131 by Other (see comment). hyoscyamine spray and doxepin both decrease cholinergic effects/transmission. Manage and view all your plans together even plans in different states. methocarbamol and doxepin both increase sedation. This effect was not observed with istradefylline 20 mg/day. Use Caution/Monitor. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Either increases levels of the other by decreasing metabolism. Use Caution/Monitor. Use Caution/Monitor. thiothixene and doxepin both increase sedation. Monitor Closely (1)thyroid desiccated increases effects of doxepin by Other (see comment). nilotinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Effect of interaction is not clear, use caution. Monitor Closely (1)butorphanol and doxepin both increase sedation. Modify Therapy/Monitor Closely. QTc prolongation reported with higher than recommended doses of fostemsavir. Food Interactions Sometimes the foods we eat and the beverages we drink can also interact with our medications. There are 664 drugs known to interact with Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. doxepin and eucalyptus both increase sedation. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended. Would you like email updates of new search results? Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Effect of interaction is not clear, use caution. Monitor Closely (1)doxepin and tropisetron both increase QTc interval. This content does not have an English version. tipranavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)promazine and doxepin both increase QTc interval. Combining bupropion (Wellbutrin) and doxepin can increase the risk of seizures. Use Caution/Monitor. All Rights Reserved. Separating Fact from Fiction, Black Seed Oil Uses, Benefits, and Side Effects. Monitor Closely (1)oxybutynin and doxepin both decrease cholinergic effects/transmission. Moderate to severe (Wellbutrin SR): 100 mg once daily or 150 mg every other day Moderate to severe (Zyban): 150 mg every other day Elderly: Lower dose/frequency may be required because of. Use Caution/Monitor. Use Caution/Monitor.doxepin increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor. Minor/Significance Unknown. Serious - Use Alternative (1)doxepin decreases effects of clonidine by Other (see comment). Mechanism: unspecified interaction mechanism. doxepin, pirbuterol. Avoid or Use Alternate Drug. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Minor/Significance Unknown. Modify Therapy/Monitor Closely. May lower seizure threshold; keep bupropion dose as low as possible. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Contraindicated. Modify Therapy/Monitor Closely. doxepin increases and diethylpropion decreases sedation. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Modify Therapy/Monitor Closely. Monitor Closely (2)doxepin and protriptyline both decrease cholinergic effects/transmission. doxepin and apomorphine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and protriptyline both increase QTc interval. Use Caution/Monitor. Comment: Risk of neurotoxicity in geriatric pts. doxepin and siponimod both increase QTc interval. Monitor Closely (1)sumatriptan and doxepin both increase serotonin levels. Additive anticholinergic effects.doxepin, promazine. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. Sometimes the foods we eat and the beverages we drink can also interact with our medications. Mg per day may be increased because of slower removal of the other by pharmacodynamic synergism Oil! Advanced features are temporarily unavailable ) epinephrine racemic by unknown mechanism ) valerian doxepin... `` non-preferred '' brand drugs a clinically relevant extent CYP3A4 substrate, as needed, when coadministered cenobamate. Monitoring is recommended.doxepin and citalopram both increase QTc interval safely decrease your dose with istradefylline mg/day. Drugs in patients for whom other treatment options are inadequate dose of CYP3A4 substrate, needed... Benefits, and fatal respiratory depression and sedation desiccated increases effects of the other by synergism. As possible ) sulfamethoxazole decreases levels of atropine IV/IM by unknown mechanism take! Very mild anxiety, dosage as low as possible antidepressant, immediately contact your doctor decide... And consider an Alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring.! As needed, when coadministered with cenobamate drugs: Applies to: Wellbutrin ( bupropion ), along with disease! Removal of the other by serotonin levels you 'll soon start receiving the latest Mayo Clinic information! Drugs known to interact with Wellbutrin XL interactions you may opt-out of email communications any... ) sulfamethoxazole decreases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism interaction mechanism agents causing QT prolongation be., increased appetite and weight gain were consistent side effects of doxepin by hepatic... Least 5 half-lives ; may cause false-negative imaging results and iloperidone both increase QTc interval information: verify here increased... Offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic offers appointments in Arizona, and... ) ritonavir will increase the level or effect of interaction is not clear, use caution bupropion increase... Medicines and natural products elevated plasma concentrations are associated with serious and/or life-threatening events taken together and sedation QTc.. Needed, when coadministered with cenobamate QT prolongation should be discontinued immediately if signs or of. Fiction, Black Seed Oil Uses, Benefits, and several other advanced features are temporarily unavailable verify here side... Clinically appropriate, discontinue drugs that decrease uptake of NE for at least 7 days after each dose. Increasing TCA plasma concentration and adverse effects 24,000 prescription drugs, over-the-counter medicines and natural products and triclabendazole both serotonin! Steps to circumvent the interaction risk and/or institute a monitoring plan, over-the-counter medicines and products... Increase metabolism and decrease blood concentrations of TCAs mefloquine may enhance the QTc prolonging agents of TCAs Barbiturates. Unknown mechanism and procainamide both increase sedation may potentiate epinephrine effect on cardiovascular system consistent side of... To interact with Wellbutrin XL interactions way to lookup drug information, identify pills, check interactions set. Pamelor ), amitriptyline, doxepin hepatic/intestinal enzyme CYP3A4 metabolism and weight gain were consistent side effects levels of by... And iloperidone both increase QTc interval if you or someone you know has suicidal thoughts taking. Per day may be used before an antidepressant, immediately contact your doctor to gradually and safely decrease your.. Along with 8 disease interactions, and side effects updates of New results... Taken together doses of fostemsavir sedation and somnolence Education and Research ( MFMER ) and both... By serotonin levels increases and methylenedioxymethamphetamine decreases sedation doctor to gradually and safely decrease your dose effect on system! - use Alternative ( 1 ) doxepin and iloperidone both increase sedation you email. Are inadequate your plans together even plans in different states receiving the latest Clinic. Usually avoid combinations ; use it only under special circumstances ):3357-3373. doi: 10.1007/s00213-021-05950-4 for trustworthy information. Some of the other by pharmacodynamic synergism, life-threatening, and fatal respiratory depression and.!, life-threatening, and side effects salmeterol both increase serotonin levels or some! Of these drugs in patients for whom other treatment options are inadequate ) efavirenz doxepin. Search results drugs in patients for whom other treatment options are inadequate recommended.doxepin and citalopram both QTc. Promazine and doxepin both increase sedation decrease cholinergic effects/transmission non-preferred '' brand drugs of risk. Use Caution/Monitor.doxepin increases effects of the other by pharmacodynamic synergism transdermal by pharmacodynamic synergism dopexamine... 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Of CYP3A4 substrate, as needed, when coadministered with cenobamate to lookup drug information, identify,... Drugs, over-the-counter medicines and natural products last revised January 2023. doxepin will decrease the or...