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2022 09; 609(7925):101-108. J Biol Chem. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. 2000 Jan; 48(1):39-44. 2011 Oct; 89(10):997-1013. 2012 Aug; 143(2):307-20. 2006 May; 130(6):1564-72. 1992 May; 4(5):43-58. 2003 Jul; 39(1):38-46. 2000 Nov 01; 28(21):4306-16. Dig Dis. Am J Physiol Gastrointest Liver Physiol. Hepatology. Proc Natl Acad Sci U S A. 1999 Jun; 19(6):4334-42. 2001; 160:459-79. Proc Natl Acad Sci U S A. 2000 Mar; 15 Suppl:D20-5. FASEB J. 2015 Feb; 4(1):34-47. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Reversibility of liver fibrosis. J Biol Chem. 2017 09 15; 331:135-141. Publisher Correction: The gut-liver axis and the intersection with the microbiome. J Biol Chem. 1998 Sep; 13 Suppl:S93-5. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Aliment Pharmacol Ther. 2010 Oct; 52(4):1420-30. Proc Natl Acad Sci U S A. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Recent advances in liver stem cell therapy. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. 1997 May; 25(5):1128-35. Mol Ther Nucleic Acids. 2013 Feb 01; 12(3):381-2. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. 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Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. 1990; 14(6):639-45. Prog. Circulation. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. 2000 Jul; 33(1):49-58. J Clin Invest. Hepatology. Activation of Jun kinase is an early event in hepatic regeneration. 2009 Sep; 50(3):929-38. PNAS Nexus. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. 1998 Jun; 42(6):779-87. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. Analysis of the human ferrochelatase promoter in transgenic mice. 2013 Mar; 37(6):630-9. 1990 Dec; 283(2):447-57. 2001 Jul 01; 167(1):173-80. Nat Clin Pract Gastroenterol Hepatol. Age (Dordr). TLR4 enhances TGF-beta signaling and hepatic fibrosis. J Clin Invest. This graph shows the number and percent of publications by field. 2012; 7(4):e34218. 2013 Jun; 45(6):450-9. Next-generation academic medicine. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. We lose people all of the time. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. 2008 Feb; 25(2):249-58. Nishimura T, Nishiura T, deSerres S, Nakagawa T. New aspects of hepatic fibrosis. Hepatology. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. UCSD Profiles is managed by the UC San Diego 1999 Aug; 14(8):1272-80. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Gut. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. 1988 Sep-Oct; 8(5):1040-5. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. 2012 Nov; 67(11):1357-64. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Hepatol. Gastroenterology. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. 2008 Nov; 135(5):1729-38. Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells. Clin Gastroenterol Hepatol. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. 2014 Dec; 60(6):1920-8. 2011 May; 53(5):1730-41. To see the data as text. 2011 Jul; 41(7):683-6. Am J Physiol. J Theor Biol. Hepatology. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Gastroenterology. 2016; 7:47. Hepatology. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. 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WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. 2019 11 05; 30(5):850-852. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. Toxicol Sci. 2008 Feb; 47(2):677-85. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. 2007 Dec 07; 249(3):518-31. 1997 Jan 17; 272(3):1753-60. 2020; 2(2):fcaa133. 2017 01 03; 127(1):55-64. Aging Ment Health. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. 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Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. 1999; 8(3):151-63. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. 2012 Jun; 10(6):575-80. Altman Clinical and Translational Research Institute (ACTRI). 2008 Feb; 233(2):109-22. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. 1998 Aug 10; 1366(1-2):177-96. Transplantation. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. 2005 Sep; 230(8):573-86. 2007 May; 132(5):1937-46. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. 2021; 12(3):891-920. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. 2005 Mar; 39(3):181-8. 1977 Dec; 60(6):1354-61. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). 2006 Aug; 116(8):2058-9. Semin Liver Dis. 2000; 35 Suppl 12:80-3. Hepatology. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. 2013 Apr; 144(4):661-3. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Best Pract Res Clin Gastroenterol. 2022 10; 610(7931):366-372. Liver Int. 2002 Sep; 132(3):441-9. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. 2020 Feb; 21(2):89-98. 2001 Jan; 33(1):81-90. J Hepatol. 2003 Feb; 124(2):445-58. J Gastroenterol Hepatol. 1993 Dec; 92(6):2916-21. Hepatology. Antioxid Redox Signal. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA. 2007 Dec; 47(6):834-43. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. He did not respond to inewsource s interview request. 1991 Jun; 87(6):2230-5. 2008 Dec; 173(6):1617-27. J Clin Invest. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. 2007 Feb; 27(1):28-43. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Liver Transpl. Cancer Res. Mol Cell Biol. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. 1998 04; 274(4):G669-76. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Akt activation protects rat liver from ischemia/reperfusion injury. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. The enteropathy of prostaglandin deficiency. J Immunol. 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Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. 2015 Mar; 29(3):1043-55. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T. Intestinal Virome in Patients With Alcoholic Hepatitis. 2002 Jul; 283(1):C347-57. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Pharm Res. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A. Cell Metab. Am J Gastroenterol. Hepatology. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. 2015 Apr; 61(4):1239-50. 1996 Nov; 271(5 Pt 1):G780-90. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. Vuori will Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. Contribution of bone marrow-derived fibrocytes to liver fibrosis. J Clin Invest. 2007 Jun; 22 Suppl 1:S73-8. Am J Clin Nutr. 2003 Nov; 285(5):G949-58. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. J Gastroenterol Hepatol. 2019 07 23; 116(30):15184-15193. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. Exp Biol Med (Maywood). 2016 Aug; 38(4):291-302. 2001 Sep; 25(9):1360-7. Gastroenterology. 2014 Dec; 26(12):1802-11. 2020 11; 41:101039. Interactions between the intestinal microbiome and liver diseases. 1995 Feb; 95(2):803-10. 1991 Mar; 5(3):275-81. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. 2011 Apr; 300(4):G516-25. J Clin Immunol. J Gastroenterol Hepatol. 2004 Oct; 121(2):159-70. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. Hepatology. Expression of collagen genes in the liver. Exercise training attenuates age-associated diastolic dysfunction in rats. Am J Physiol Gastrointest Liver Physiol. 2020; 15(6):e0234038. Cloning of murine ferrochelatase. 2020 May 05; 56(5). 1998 Feb; 2(1):77-102, vi. Gut. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. 2012 May 22; 109(21):E1369-76. 2010 Jul-Aug; 19(4):311-20. To return to the graph. Integr Biol (Camb). Hepatology. 2011 Mar 11; 286(10):8609-8619. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Cell Metab. Expression of human immunodeficiency virus-1 in human colonic cells. 2017 May 02; 25(5):1054-1062.e5. medRxiv. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. Nat Med. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. Proc Natl Acad Sci U S A. PLoS One. 1999 Jan; 30(1):77-87. WebDavid Brenner. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. Am J Physiol. DNA. 2012; 5(Suppl 1):S17. Fibrogenesis of parenchymal organs. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. Trans Am Clin Climatol Assoc. 2001 Nov; 34(5):953-63. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. Hepatology. Am J Physiol Cell Physiol. 1995 Jul; 22(1):241-51. Gastroenterology. J Biol Chem. J Clin Invest. J Immunol. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. 1989 Aug 11; 17(15):6055-64. DNA Cell Biol. FASEB J. Proc Natl Acad Sci U S A. 2015 Sep; 39 Suppl 1:S75-9. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Gastroenterology. Immunol Res. Mechanisms of hepatic toxicity. 1985 Apr; 5(4):684-91. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Brain. J Biol Chem. 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To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. 2002 Mar; 82(3):323-33. 2009 May; 40(5):1721-8. Alcohol Clin Exp Res. Kenji Fujiwara, MD, PhD. Data from arrays: an embarrassment of riches. Signal transduction during liver regeneration. Liver Transpl. DNA Cell Biol. USC undermined our ability to do research. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. 2020 02 13; 5(3). Hepatology. 2001 May; 25(5 Suppl ISBRA):251S-253S. 2000 Feb; 31(2):391-8. People in Profiles who have published with this person. Proc Natl Acad Sci U S A. 1989 May; 9(5):2224-7. J Clin Exp Hepatol. 1999; 66:205-22. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Am J Physiol. 2014 Jul; 124(7):2921-34. 1993 Sep; 92(3):1336-48. J Burn Care Rehabil. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. 2001 Jun; 280(6):G1178-86. 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What is the potential role of antifibrotic agents for the treatment of liver disease? 2002 Sep; 123(3):877-8. 1995 Jun; 21(6):303-7. 1999 Jan 06; 1453(1):161-74. 1991 12; 54(6 Suppl):1141S-1143S. Exp Neurol. 2007 Apr; 132(4):1434-46. Hepatology. 2020; 4(5):561-580. 2001 Dec; 35(6):749-55. 2014 Aug 12; 111(32):E3297-305. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. 2019 01; 49(2):183-193. 1994 Dec; 124(6):755-60. 1987 Sep; 79(3):449-56. 2003 Mar; 37(3):653-64. Hepatol Commun. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. New Developments on the Treatment of Liver Fibrosis. 2022 07; 10(7):e1953. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. J Biol Chem. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. PLoS One. 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